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Drug Interactions between DHEA and estramustine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

estramustine dehydroepiandrosterone (prasterone)

Applies to: estramustine and DHEA (dehydroepiandrosterone)

GENERALLY AVOID: The safety and efficacy of combining dehydroepiandrosterone (also known as prasterone or DHEA) with other hormonal treatments containing estrogens or androgens has not been evaluated. Use with other estrogens and androgens could result in additive adverse effects as DHEA is a precursor steroid that is converted into estrogens and androgens.

MANAGEMENT: Concomitant use of dehydroepiandrosterone (also known as prasterone or DHEA) with other hormonal treatments containing androgens or estrogens should generally be avoided.

References (2)
  1. (2023) "Product Information. Intrarosa (prasterone)." Theramex Australia Pty Ltd, 1
  2. (2022) "Product Information. Intrarosa (prasterone)." Theramex HQ UK Ltd

Drug and food interactions

Moderate

estramustine food

Applies to: estramustine

ADJUST DOSING INTERVAL: Food and milk may significantly decrease serum concentrations of estramustine. The mechanism of the interaction is not known.

MANAGEMENT: It is recommended that estramustine be taken at least 1 hour before or 2 hours after meals, and that it not be coadministered with milk, or calcium containing products.

References (1)
  1. (2001) "Product Information. Emcyt (estramustine)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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