Drug Interactions between DHEA and estradiol

Dehydroepiandrosterone (prasterone) is a hormone that occurs naturally in your body and can be broken down to create the sex steroids testosterone (androgen) and estradiol (estrogen). Using dehydroepiandrosterone (prasterone) together with other sex steroid containing products such as estradiol may lead to an increase in side effects. The risk of this interaction might be reduced when one medication is administered topically or vaginally as less of the sex steroids are expected to reach your blood stream. Some of the more serious side effects of these types of therapies include blood clots (chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; trouble speaking or swallowing); cancer (breast, ovarian, prostate); gallbladder problems (pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever; bloating; upset stomach or vomiting); high blood pressure; liver problems (dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, vomiting, yellow skin or eyes); stroke (weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on 1 side of the face, blurred eyesight); mood changes; and memory problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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