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Drug Interactions between dexmethylphenidate and risperidone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

risperiDONE dexmethylphenidate

Applies to: risperidone and dexmethylphenidate

MONITOR: The coadministration of risperidone with serdexmethylphenidate, dexmethylphenidate, or methylphenidate, when there is an increase or decrease of dosage of either medication, may increase the risk of extrapyramidal symptoms. The mechanism of this interaction has not been delineated.

MANAGEMENT: Caution is advised if risperidone must be used concomitantly with methylphenidate, dexmethylphenidate, or serdexmethylphenidate. Patients should be monitored more closely whenever either drug is added to or withdrawn from therapy and whenever either dosage is changed. Patients should be monitored for the development of extrapyramidal symptoms (e.g., tremor, shuffling gait, drooling, mask-like face, tongue stiffness, muscle spasms or rigidity, involuntary movements) and changes in mental status.

References (5)
  1. (2001) "Product Information. Risperdal (risperidone)." Janssen Pharmaceuticals
  2. (2005) "Product Information. Risperdal Consta (risperidone)." Janssen Pharmaceuticals
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  4. Cerner Multum, Inc. "Australian Product Information."
  5. (2021) "Product Information. Azstarys (dexmethylphenidate-serdexmethylphenidate)." Corium, Inc.

Drug and food interactions

Moderate

risperiDONE food

Applies to: risperidone

GENERALLY AVOID: Risperidone oral solution is not compatible with either tea or cola. In addition, alcohol may potentiate some of the pharmacologic effects of risperidone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Risperidone oral solution should not be mixed with tea or cola. It may be taken with water, coffee, orange juice, or lowfat milk. Patients should also be advised to avoid consumption of alcohol.

References (1)
  1. (2001) "Product Information. Risperdal (risperidone)." Janssen Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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