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Drug Interactions between dexmethylphenidate and phenylbutazone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

phenylbutazone dexmethylphenidate

Applies to: phenylbutazone and dexmethylphenidate

MONITOR: The coadministration with methylphenidate may increase the plasma concentrations of phenylbutazone. According to the manufacturer, human pharmacologic studies have shown that methylphenidate may inhibit the metabolism of phenylbutazone.

MANAGEMENT: Pharmacologic response to phenylbutazone should be monitored more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the phenylbutazone dosage adjusted as necessary.

References (1)
  1. (2001) "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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