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Drug Interactions between dexmethylphenidate and mibefradil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mibefradil dexmethylphenidate

Applies to: mibefradil and dexmethylphenidate

MONITOR: Methylphenidate and other derivative amphetamines may decrease the therapeutic effects of antihypertensive drugs. According to serdexmethylphenidate label information, CNS stimulants cause a mean increase in blood pressure of approximately 2 to 4 mmHg and a mean increase in heart rate of approximately 3 to 6 beats per minute. With some individuals having larger increases.

MANAGEMENT: Caution and monitoring of blood pressure is recommended if methylphenidate, dexmethylphenidate or serdexmethylphenidate are administered with antihypertensives agents such as: potassium-sparing and thiazide diuretics, calcium channel blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers or centrally acting alpha-2 receptor agonists. The dosage of the antihypertensive drug should be adjusted as needed.

References

  1. (2001) "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals
  2. (2022) "Product Information. Metadate CD (methylphenidate)." Celltech Pharmaceuticals Inc
  3. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  4. (2002) "Product Information. Metadate ER (methylphenidate)." Celltech Pharmaceuticals Inc
  5. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  6. Cerner Multum, Inc. "Australian Product Information."
  7. (2013) "Product Information. Ritalin LA (methylphenidate)." Quality Care Products/Lake Erie Medical
  8. (2021) "Product Information. Azstarys (dexmethylphenidate-serdexmethylphenidate)." Corium, Inc.
View all 8 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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