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Drug Interactions between dexamethasone / lidocaine and Lamictal

This report displays the potential drug interactions for the following 2 drugs:

  • dexamethasone/lidocaine
  • Lamictal (lamotrigine)

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Interactions between your drugs

Moderate

lidocaine lamoTRIgine

Applies to: dexamethasone / lidocaine and Lamictal (lamotrigine)

Consumer information for this interaction is not currently available.

MONITOR: In vitro studies have shown lamotrigine exhibits class IB antiarrhythmic activity at therapeutically relevant concentrations. Based on this data, there is a concern that concomitant use of other sodium channel blockers may increase the risk of proarrhythmias. In healthy individuals, a thorough QT study did not show slowed ventricular conduction (widen QRS); however, slow ventricular conduction and proarrhythmias may occur in patients with structural heart disease or myocardial ischemia.

MANAGEMENT: Caution and clinical monitoring are recommended if concomitant use of other sodium channel blockers is needed as this may increase the risk of proarrhythmias. The manufacturer recommends lamotrigine be avoided in patients who have cardiac conduction disorders (e.g., second- or third-degree heart block), ventricular arrhythmias, or cardiac disease or abnormality (e.g., myocardial ischemia, heart failure, structural heart disease, Brugada syndrome or other sodium channelopathies) as use may increase the risk of proarrhythmias including sudden death. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate an irregular heart rhythm such as dizziness, lightheadedness, fainting, palpitation, shortness of breath, or syncope.

References

  1. "Product Information. Lamictal (lamotrigine)." Glaxo Wellcome, Research Triangle Park, NC.
  2. "Product Information. LaMICtal XR (lamoTRIgine)." GlaxoSmithKline, Research Triangle Park, NC.
Minor

lidocaine dexamethasone

Applies to: dexamethasone / lidocaine and dexamethasone / lidocaine

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Drug and food interactions

Moderate

lamoTRIgine food

Applies to: Lamictal (lamotrigine)

Alcohol can increase the nervous system side effects of lamoTRIgine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with lamoTRIgine. Do not use more than the recommended dose of lamoTRIgine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.