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Drug Interactions between desmopressin and remifentanil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

desmopressin remifentanil

Applies to: desmopressin and remifentanil

Remifentanil can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death. You should seek immediate medical attention if you experience loss of appetite, nausea, vomiting, drowsiness, fatigue, weakness, headache, confusion, difficulty concentrating, memory impairment, decreased urination, and/or sudden weight gain, as these may be early signs and symptoms of water intoxication and hyponatremia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food/lifestyle interactions

Major

remifentanil food/lifestyle

Applies to: remifentanil

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur. In addition, alcohol may affect opioid release from sustained-release formulations.

MANAGEMENT: Patients should not consume alcoholic beverages or use drug products that contain alcohol during treatment with opioid analgesics. Any history of alcohol or illicit drug use should be considered when prescribing an opioid analgesic, and therapy initiated at a lower dosage if necessary. Patients should be closely monitored for signs and symptoms of sedation, respiratory depression, and hypotension.

Minor

desmopressin food/lifestyle

Applies to: desmopressin

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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