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Drug Interactions between desflurane and dihydrocodeine / guaifenesin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

desflurane dihydrocodeine

Applies to: desflurane and dihydrocodeine / guaifenesin

MONITOR: Opioids may decrease the minimum alveolar concentration required for inhalation anesthetics. When these agents are used concomitantly, less inhalation anesthetic may be required. In addition, inhalation anesthetics may cause respiratory depression which may be increased by opioid premedication or other agents causing respiratory depression.

MANAGEMENT: In general, anesthesia should be titrated to clinical effect by those experienced in anesthesia technique and in the care of patients receiving opioids. Patients should be monitored closely for respiratory depression. Supportive therapy should be provided if needed.

References (2)
  1. (2001) "Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical
  2. Inagaki Y, Kuzukawa A (1997) "Effects of epidural and intravenous buprenorphine on halothane minimum alveolar anesthetic concentration and hemodynamic responses." Anesth Analg, 84, p. 100-5

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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