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Drug Interactions between deserpidine and Urolene Blue

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

methylene blue deserpidine

Applies to: Urolene Blue (methylene blue) and deserpidine

GENERALLY AVOID: The addition of a rauwolfia alkaloid to existing monoamine oxidase inhibitor (MAOI) therapy may result in profound excitation and/or a hypertensive reaction. The proposed mechanism is increased norepinephrine levels at adrenergic receptors due to both the inhibition of catecholamine metabolism by MAOIs and the release of catecholamines induced by rauwolfia alkaloids. Theoretically, this interaction should not occur if rauwolfia alkaloid therapy is initiated several days before the start of MAOI therapy. However, clinical data are limited.

MANAGEMENT: In general, rauwolfia alkaloids should not be administered to patients treated with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with rauwolfia alkaloids.

References (5)
  1. Pettinger WA, Soyangco FG, Oates JA (1968) "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther, 9, p. 442-7
  2. Schulz R, Antonin KH, Hoffmann E, et al. (1989) "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther, 46, p. 528-36
  3. Goldberg LI (1964) "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA, 190, p. 456-62
  4. Sherman GP, Walton CA (1975) "Adrenergic transmission and drug interaction." J Am Pharm Assoc, 15, p. 86-90
  5. De Vita VT, Hahn MA, Oliverio VT (1965) "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med, 120, p. 561-5

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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