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Drug interactions between denosumab and zoledronic acid

Results for the following 2 drugs:
denosumab
zoledronic acid

Interactions between your drugs

Moderate

zoledronic acid ↔ denosumab

Applies to:zoledronic acid and denosumab

Both denosumab and zoledronic acid can cause a rare but serious condition known as osteonecrosis of the jaw (ONJ), and combining these medications may increase the risk. ONJ is the exposure of jaw bone through the gums associated with death of bone tissue and usually occurs after invasive dental procedures such as tooth extraction. Severe cases may require surgery. The risk is generally related to the dose of these medications and the duration of treatment. Because zoledronic acid can remain in the bone for years, the risk may exist for some time even after you have stopped taking it. Good oral hygiene and regular dental care is the best way to lower the risk of ONJ. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek medical attention if you experience potential signs and symptoms of ONJ such as: pain in the mouth, teeth, or jaw; swelling or sores inside the mouth; numbness or a feeling of heaviness in the jaw; loosening of a tooth; or exposure of bone in the jaw. Also, before you get any type of dental surgery, be sure to let your care provider know you are taking these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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