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Drug Interactions between deferiprone and milk thistle

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

milk thistle deferiprone

Applies to: milk thistle and deferiprone

GENERALLY AVOID: Coadministration of deferiprone with uridine diphosphate glucuronosyltransferase (UGT) 1A6 inhibitors may increase the plasma concentrations of deferiprone, which is metabolized by the enzyme. An in vitro study has shown coadministration of deferiprone with phenylbutazone (UGT1A6 inhibitor) decreased glucuronidation to 3-O-glucuronide (the major inactive metabolite of deferiprone) by up to 78%.

MANAGEMENT: The use of deferiprone with UGT1A6 inhibitors should be avoided.

References

  1. (2011) "Product Information. Ferriprox (deferiprone)." ApoPharma USA Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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