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Drug Interactions between Decadron with Xylocaine and Xeljanz

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

dexAMETHasone tofacitinib

Applies to: Decadron with Xylocaine (dexamethasone / lidocaine) and Xeljanz (tofacitinib)

Using tofacitinib together with dexAMETHasone may increase the risk of serious and potentially fatal infections. In some cases, combining medications that affect the bone marrow or immune system can also increase the risk of various types of cancer over time. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. In addition, using tofacitinib together with dexAMETHasone may have additive adverse effects and increase the risk of diverticular disease or gastrointestinal bleeding or perforation. Contact your doctor if you experience severe abdominal pain, fever, nausea, or vomiting. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

lidocaine tofacitinib

Applies to: Decadron with Xylocaine (dexamethasone / lidocaine) and Xeljanz (tofacitinib)

Using tofacitinib together with lidocaine is not recommended. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. You may need a dose adjustment or special tests to safely take both medications together. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, slow pulse, or irregular heartbeat during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

lidocaine dexAMETHasone

Applies to: Decadron with Xylocaine (dexamethasone / lidocaine) and Decadron with Xylocaine (dexamethasone / lidocaine)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Moderate

lidocaine food

Applies to: Decadron with Xylocaine (dexamethasone / lidocaine)

Grapefruit juice may increase the blood levels of lidocaine, which may increase the risk of side effects such as low blood pressure, slow heart rate, irregular heart rhythm, difficulty breathing and convulsions. Cigarette smoking may reduce the blood levels of lidocaine, which may make the medication less effective. It is best to avoid smoking during lidocaine therapy. Consuming cruciferous vegetables (e.G., broccoli, brussels sprouts) may also reduce the blood levels of lidocaine. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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