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Drug Interactions between darifenacin and prabotulinumtoxinA

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

darifenacin prabotulinumtoxinA

Applies to: darifenacin and prabotulinumtoxinA

MONITOR: Use of anticholinergic drugs after administration of botulinum toxin may potentiate systemic anticholinergic effects such as dry mouth, blurred vision, and urinary disorders. Botulinum toxin inhibits the release of acetylcholine from peripheral cholinergic nerve endings, thus additive or synergistic anticholinergic effects may occur when these agents are used together.

MANAGEMENT: Patients should be advised that systemic anticholinergic side effects such as dry mouth, blurred vision, and urinary disorders may increase if agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) are used after administration of botulinum toxin.

References (8)
  1. "Product Information. Myobloc (rimabotulinumtoxinB)." Elan Pharmaceuticals
  2. "Product Information. Dysport (abobotulinumtoxinA)." Tercica Inc
  3. "Product Information. Botox (onabotulinumtoxinA)." Allergan Inc
  4. (2022) "Product Information. Xeomin (incobotulinumtoxinA)." Merz Pharmaceuticals
  5. (2022) "Product Information. Jeuveau (prabotulinumtoxinA)." Evolus, Inc.
  6. (2022) "Product Information. Daxxify (daxibotulinumtoxinA)." Revance Therapeutics, Inc., 1
  7. (2022) "Product Information. Letybo (letibotulinumtoxinA)." CROMA Australia Pty Ltd, 1
  8. (2024) "Product Information. Letybo (letibotulinumtoxinA)." Hugel Aesthetics

Drug and food interactions

Minor

darifenacin food

Applies to: darifenacin

The consumption of grapefruit juice may be associated with increased plasma concentrations of darifenacin. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The clinical significance is unknown.

References (1)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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