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Drug Interactions between dapsone topical and trimethoprim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

trimethoprim dapsone topical

Applies to: trimethoprim and dapsone topical

Systemic levels of dapsone and its metabolites following topical administration may be increased in the presence of trimethoprim/sulfamethoxazole (TMP/SMX). In a drug interaction study, systemic exposure (AUC) of dapsone and N-acetyl-dapsone were increased by about 40% and 20%, respectively, during coadministration with double-strength (160 mg/800 mg) TMP/SMX. Systemic exposure of dapsone hydroxylamine, a metabolite associated with hemolysis, was more than doubled by TMP/SMX. The clinical significance of these changes is unknown. Exposure from the recommended topical dose for acne vulgaris is about 1% of that from a 100 mg oral dose, even when coadministered with TMP/SMX. There were no effects on the systemic levels of TMP or SMX.

References (1)
  1. (2005) "Product Information. Aczone (dapsone topical)." QLT USA, Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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