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Drug Interactions between Cytoxan and Doxil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

cycloPHOSphamide DOXOrubicin liposomal

Applies to: Cytoxan (cyclophosphamide) and Doxil (doxorubicin liposomal)

A single case report suggests that doxorubicin may enhance the risk of hemorrhagic cystitis associated with cyclophosphamide. Animal data have shown that cyclophosphamide can decrease the formation of inactive metabolites of doxorubicin. The clinical relevance of these data is unknown, and more data are needed.

References

  1. Ershler WB, Gilchrist KW, Citrin DL (1980) "Adriamycin enhancement of cyclophoshamide-induced bladder injury." J Urol, 123, p. 121-2
  2. Dodion P, Akman SR, Tamburini JM, Riggs CE Jr, Colvin OM, Bachur NR (1986) "Interactions between cyclophosphamide and doxorubicin metabolism in rats. II. Effect of cyclophosphamide on the aldoketoreductase system." J Pharmacol Exp Ther, 237, p. 271-4

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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