Drug Interactions between cytarabine liposomal / daunorubicin liposomal and sargramostim
This report displays the potential drug interactions for the following 2 drugs:
- cytarabine liposomal/daunorubicin liposomal
- sargramostim
Interactions between your drugs
sargramostim DAUNOrubicin liposomal
Applies to: sargramostim and cytarabine liposomal / daunorubicin liposomal
ADJUST DOSING INTERVAL: The safety and efficacy of hematopoietic growth factors such as colony-stimulating factors (G-CSF and GM-CSF) and stem cell factors (SCF) given simultaneously with cancer chemotherapy have not been established. Theoretical concerns exist regarding their concomitant administration because hematopoietic growth factors stimulate myeloid cell proliferation while antineoplastic agents primarily target rapidly dividing cells.
MANAGEMENT: Because of the potential sensitivity of rapidly dividing myeloid cells to cancer chemotherapy, hematopoietic growth factors should not be used within 24 hours before or 24 hours after administration of antineoplastic agents.
References
- "Product Information. Neupogen (filgrastim)." Amgen PROD (2002):
- "Product Information. Leukine (sargramostim)." Immunex Corporation PROD (2001):
- "Product Information. Stemgen (ancestim)." Amgen PROD (2001):
- "Product Information. Granix (tbo-filgrastim)." Teva Pharmaceuticals USA (2013):
DAUNOrubicin liposomal cytarabine liposomal
Applies to: cytarabine liposomal / daunorubicin liposomal and cytarabine liposomal / daunorubicin liposomal
MONITOR: The concomitant or sequential administration of multiple antineoplastic agents may result in additive toxicities, particularly in the bone marrow, gastrointestinal tract and heart.
MANAGEMENT: Close clinical and laboratory monitoring for hematologic and nonhematologic toxicities are recommended when antineoplastic agents are administered concurrently or during close intervals. Dosing adjustments may be necessary. The manufacturers' recommendations and institutional protocols for dosage, treatment regimens, monitoring, and management of toxicities should be consulted.
References
- "Product Information. Paraplatin (carboplatin)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb PROD (2001):
- "Product Information. Fluorouracil (fluorouracil)." Roche Laboratories (2022):
- "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Ellence (epirubicin)." Pharmacia and Upjohn PROD (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid" (2007):
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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