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Drug Interactions between Cytadren and Mudrane GG-2

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

aminoglutethimide aminophylline

Applies to: Cytadren (aminoglutethimide) and Mudrane GG-2 (aminophylline / guaifenesin)

MONITOR: Aminoglutethimide may significantly reduce theophylline serum concentrations by increasing theophylline clearance. The mechanism is induction of CYP450 3A4 hepatic microsomal enzymes. One study noted an increase of 32% in theophylline clearance. Conversely, theophylline toxicity may occur after aminoglutethimide is discontinued.

MANAGEMENT: The patient should be monitored for clinical and laboratory evidence of altered theophylline response when aminoglutethimide is added, discontinued, or the dosage is changed. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms during concurrent therapy.

References

  1. Lonning PE, Kvinnsland S, Bakke OM "Effect of aminoglutethimide on antipyrine, theophylline, and digitoxin disposition in breast cancer." Clin Pharmacol Ther 36 (1984): 796-802

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Drug and food interactions

Moderate

aminophylline food

Applies to: Mudrane GG-2 (aminophylline / guaifenesin)

MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.

MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.

References

  1. Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res 1 (1979): 45-52
  2. Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
  3. "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc PROD (2001):
  4. "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals PROD (2001):
  5. "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals PROD (2001):
  6. "Product Information. Focalin (dexmethylphenidate)." Mikart Inc (2001):
  7. "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company (2002):
View all 7 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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