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Drug Interactions between Cysview and valrubicin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

valrubicin hexaminolevulinate

Applies to: valrubicin and Cysview (hexaminolevulinate)

CONTRAINDICATED: Inflammation of bladder resulting from the use of BCG immunotherapy or intravesical chemotherapy may interfere with the diagnostic utility of hexaminolevulinate, which is an ester of the heme precursor, aminolevulinic acid. Following intravesical instillation of hexaminolevulinate, photoactive porphyrins are formed and accumulate intracellularly in bladder wall lesions. In humans, a higher degree of accumulation of porphyrins has been demonstrated in neoplastic or inflamed cells compared to normal bladder urothelium. As such, inflammation may lead to increased porphyrin buildup and higher risk of local toxicity upon illumination as well as false-positive fluorescence.

MANAGEMENT: The use of hexaminolevulinate is considered contraindicated in patients given BCG immunotherapy or intravesical chemotherapy within the past 90 days due to a high risk of bladder inflammation in these patients. Widespread inflammation of the bladder should be excluded by cystoscopy before hexaminolevulinate is administered. If a widespread inflammation in the bladder becomes evident during white light inspection, the blue light inspection should be avoided.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2014) "Product Information. Cysview (hexaminolevulinate)." Photocure Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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