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Drug Interactions between cyclophosphamide and peginterferon alfa-2b

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

cycloPHOSphamide peginterferon alfa-2b

Applies to: cyclophosphamide and peginterferon alfa-2b

Human lymphoblastoid interferon has been shown to enhance the antitumor activity of doxorubicin and cyclophosphamide in animal models by delaying the G2 cell division phase and increasing the number of cells in the S phase. The clinical significance of this finding is unknown.

References

  1. Balkwill FR, Mowshowitz S, Seilman SS, et al. "Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes." Cancer Res 44 (1984): 5249-55
  2. Kang Y, Perry RR "Modulatory effects of tamoxifen and recombinant human alpha- interferon on doxorubicin resistance." Cancer Res 53 (1993): 3040-5

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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