Drug Interactions between Coxanto and omacetaxine
This report displays the potential drug interactions for the following 2 drugs:
- Coxanto (oxaprozin)
- omacetaxine
Interactions between your drugs
oxaprozin omacetaxine
Applies to: Coxanto (oxaprozin) and omacetaxine
GENERALLY AVOID: Coadministration of omacetaxine and drugs that interfere with platelet function or coagulation may potentiate the risk of bleeding complications. Treatment with omacetaxine is associated with a high frequency of thrombocytopenia. In one study, the overall incidence of grade 3 and 4 thrombocytopenia was 85% and 88%. Fatal cerebral hemorrhages occurred in 2% of patients receiving omacetaxine and nonfatal gastrointestinal hemorrhages occurred in 2%.
MANAGEMENT: Concomitant use of other medications that interfere with platelet function or coagulation should be avoided if the patient's platelet count is less than 50,000 per microliter. Close clinical and laboratory observation for bleeding complications is recommended during therapy. The CBC and platelet count should be monitored according to the manufacturer's recommendations. Patients should be advised to immediately report signs of hemorrhage including unusual bleeding, bruising, blood in the urine or feces, confusion, blurry vision, or slurred speech.
References
- (2012) "Product Information. Synribo (omacetaxine)." Teva Pharmaceuticals USA
Drug and food interactions
oxaprozin food
Applies to: Coxanto (oxaprozin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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