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Drug Interactions between Cotrim and Vaxchora

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

sulfamethoxazole cholera vaccine, live

Applies to: Cotrim (sulfamethoxazole / trimethoprim) and Vaxchora (cholera vaccine, live)

ADJUST DOSING INTERVAL: The use of live, attenuated cholera vaccine with systemic antibiotics may result in a diminished immunologic response to the vaccine. Some antibiotics may be active against the vaccine strain of Vibrio cholerae, thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response.

MANAGEMENT: Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.

References

  1. "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):

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Major

trimethoprim cholera vaccine, live

Applies to: Cotrim (sulfamethoxazole / trimethoprim) and Vaxchora (cholera vaccine, live)

ADJUST DOSING INTERVAL: The use of live, attenuated cholera vaccine with systemic antibiotics may result in a diminished immunologic response to the vaccine. Some antibiotics may be active against the vaccine strain of Vibrio cholerae, thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response.

MANAGEMENT: Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.

References

  1. "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):

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Drug and food interactions

Moderate

cholera vaccine, live food

Applies to: Vaxchora (cholera vaccine, live)

ADJUST DOSING INTERVAL: There are no data regarding the concurrent administration of cholera oral vaccine with food or beverages.

MANAGEMENT: The manufacturer recommends that patients avoid eating or drinking for 60 minutes before and after administration of cholera oral vaccine.

References

  1. "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):

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Moderate

sulfamethoxazole food

Applies to: Cotrim (sulfamethoxazole / trimethoprim)

MONITOR: Two cases have been reported in which patients on sulfamethoxazole-trimethoprim therapy, after consuming beer, reported flushing, heart palpitations, dyspnea, headache, and nausea (disulfiram - alcohol type reactions). First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol by inhibiting acetaldehyde dehydrogenase and subsequently causing acetaldehyde accumulation. Since sulfamethoxazole is chemically related to first-generation sulfonylureas, a disulfiram-like reaction with products containing sulfamethoxazole is theoretically possible. However, pharmacokinetic/pharmacodynamic data are lacking and in addition, the two reported cases cannot be clearly attributed to the concomitant use of sulfamethoxazole-trimethoprim and alcohol.

MANAGEMENT: Patients should be alerted to the potential for this interaction and although the risk for this interaction is minimal, caution is recommended while taking sulfamethoxazole-trimethoprim concomitantly with alcohol.

References

  1. Heelon MW, White M "Disulfiram-cotrimoxazole reaction." Pharmacotherapy 18 (1998): 869-70
  2. Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA "Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions." Antimicrob Agents Chemother 64 (2020): e02167-19

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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