Drug Interactions between Copper and penicillamine

You may experience reduced absorption of penicillAMINE in the presence of food. The effectiveness of the antibiotic may be reduced. PenicillAMINE should be administered one hour before or two hours after meals and at least one hour apart from any other drug, food, or milk. This will make it easier for your body to absorb the medication.

PenicillAMINE and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of penicillAMINE into the bloodstream and reduce its effectiveness. You should take multivitamin with minerals at least 2 hours before or 2 hours after the penicillAMINE dose, penicillAMINE should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep (magnesium/potassium/sodium sulfates), or penicillAMINE and multivitamin with minerals should be taken as directed by your healthcare provider. Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

The use of penicillamine is contraindicated in patients with a history of penicillamine-related aplastic anemia or agranulocytosis.

Penicillamine is considerably excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. The use of penicillamine is contraindicated in patients with renal dysfunction. Proteinuria and/or hematuria may develop during therapy and may lead to nephrotic syndrome. Monitoring for proteinuria and hematuria is recommended. Caution should be taken and routine monitoring of renal function is recommended.

Penicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.

Penicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.

The trace elements, copper and manganese, are excreted in the bile. Copper and manganese doses may need to be adjusted, reduced, or omitted in patients with liver disease or biliary obstruction.

Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.

The use of penicillamine has been associated with fatalities due to certain diseases such as Goodpasture's syndrome, and myasthenia gravis. Caution is advised in patients with these conditions.

Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.

The trace elements, copper and manganese, are excreted in the bile. Copper and manganese doses may need to be adjusted, reduced, or omitted in patients with liver disease or biliary obstruction.

The trace metals manganese, chromium, copper, selenium, and zinc are absorbed in the GI tract from dietary sources and following administration of oral supplements. GI absorption may be decreased in patients with malabsorption syndromes. Therefore, larger dosages may be required when these supplements are given orally. Parenteral administration may be appropriate.

The use of penicillamine has been associated with fatalities due to certain diseases such as Goodpasture's syndrome, and myasthenia gravis. Caution is advised in patients with these conditions.