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Drug Interactions between colistimethate and polymyxin b

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

polymyxin B sulfate colistimethate

Applies to: polymyxin b and colistimethate

MONITOR: Increased adverse effects are possible when glycopeptide, polypeptide, or polymyxin antibiotics are administered concomitantly with other potentially nephrotoxic and neurotoxic drugs.

MANAGEMENT: If these drugs must be used together, renal function, auditory and vestibular function, and serum drug concentrations should be monitored.

References

  1. "Product Information. Vancocin (vancomycin)." Lilly, Eli and Company PROD (2001):
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother 70 (2015): 1903-7

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Polymyxins

Therapeutic duplication

The recommended maximum number of medicines in the 'polymyxins' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'polymyxins' category:

  • colistimethate
  • polymyxin b

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer