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Drug Interactions between cocaine nasal and disulfiram

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

disulfiram cocaine nasal

Applies to: disulfiram and cocaine nasal

GENERALLY AVOID: Disulfiram may increase the plasma concentrations of cocaine. The mechanism of interaction has not been established. Multiple double-blind, placebo-controlled studies have reported increased cocaine exposure following coadministration of disulfiram. However, conflicting data exist regarding the effect of this interaction on cocaine-associated cardiovascular and behavioral responses.

MANAGEMENT: In lieu of additional information, cocaine should be avoided, and other local anesthetic agents considered, in patients taking disulfiram.

References (5)
  1. McCance-Katz EF, Kosten TR, Jatlow P (1998) "Disulfiram effects on acute cocaine administration." Drug Alcohol Depend, 52, p. 27-39
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Roache JD, Kahn R, Newton TF, et al. (2011) "A double-blind, placebo-controlled assessment of the safety of potential interactions between intravenous cocaine, ethanol, and oral disulfiram." Drug Alcohol Depend, 119, p. 37-45
  4. (2018) "Product Information. Cocaine Hydrochloride Nasal (cocaine nasal)." Genus Lifesciences Inc.
  5. Baker JR, Jatlow P, McCance-Katz E (2007) "Disulfiram effects on responses to intravenous cocaine." Drug Alcohol Depend, 87, p. 202-9

Drug and food interactions

Major

disulfiram food

Applies to: disulfiram

CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.

MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.

References (3)
  1. Jones RO (1949) "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J, 60, p. 609-12
  2. Stoll D, King LE (1980) "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA, 244, p. 2045
  3. van Ieperen L (1984) "Sudden death during disulfiram-ethanol reaction." S Afr Med J, 66, p. 165

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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