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Drug Interactions between cobicistat / darunavir and vincristine liposome

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

vinCRIStine liposome cobicistat

Applies to: vincristine liposome and cobicistat / darunavir

Talk to your doctor before using vinCRIStine liposome together with cobicistat. Combining these medications may significantly increase the blood levels and effects of vinCRIStine liposome. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience increased side effects of vinCRIStine liposome such as constipation, abdominal pain or bloating, difficulty urinating, numbness or tingling in hands and feet, muscle weakness, difficulty walking, hearing loss, seizures, unusual or excessive bleeding, easy bruising, paleness, fatigue, fainting, infection, fever, chills, sore throat, or other flu-like symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

darunavir vinCRIStine liposome

Applies to: cobicistat / darunavir and vincristine liposome

Darunavir may increase the blood levels and effects of vinCRIStine liposome. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

darunavir food

Applies to: cobicistat / darunavir

Food can enhance the levels of darunavir in your body. Take darunavir with food. The type of food does not matter. This will make it easier for your body to absorb the medication. Swallow the whole tablets with a drink such as water or milk. Do not chew the tablets. Darunavir must be always be taken together at the same time as another medication called ritonavir (Norvir).

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer