Skip to Content

Drug Interactions between Clomid and Osphena

This report displays the potential drug interactions for the following 2 drugs:

  • Clomid (clomiphene)
  • Osphena (ospemifene)

Edit list (add/remove drugs)

Interactions between your drugs


clomiPHENE ospemifene

Applies to: Clomid (clomiphene) and Osphena (ospemifene)

Talk to your doctor before using ospemifene together with clomiPHENE. Both medications may have similar effects on certain tissues in the body. Therefore, combining them may increase the risk of side effects such as blood clots, stroke, and some cancers. You should seek immediate medical attention if you experience chest pain, shortness of breath, and/or pain or swelling in the arms or legs during treatment with either medication. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions


ospemifene food

Applies to: Osphena (ospemifene)

Food significantly increases the absorption of ospemifene. You should take ospemifene with a meal, preferably at the same time each day. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

Switch to professional interaction data

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.


Selective estrogen receptor modulators

Therapeutic duplication

The recommended maximum number of medicines in the 'selective estrogen receptor modulators' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'selective estrogen receptor modulators' category:

  • Clomid (clomiphene)
  • Osphena (ospemifene)

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.