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Drug Interactions between Clolar and tafenoquine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

clofarabine tafenoquine

Applies to: Clolar (clofarabine) and tafenoquine

GENERALLY AVOID: Coadministration with tafenoquine may increase the plasma concentrations of drugs that are substrates of organic cation transporter-2 (OCT2) or multidrug and toxin extrusion (MATE) transporters. Clinical drug interaction studies with tafenoquine and OCT2 and MATE substrates have not been conducted in humans. However, in vitro observations suggest the potential for increased concentrations of these substrates, which may result in increased toxicities. Specifically, tafenoquine inhibited metformin transport via human OCT2, MATE-1, and MATE2-K transporters in vitro.

MANAGEMENT: Concomitant use of tafenoquine with OCT2 and MATE substrates should generally be avoided. If coadministration is required, patients should be monitored for drug-related toxicities and dosage reductions considered as needed in accordance with the product labeling of the coadministered drugs.

References (1)
  1. (2018) "Product Information. Krintafel (tafenoquine)." GlaxoSmithKline

Drug and food interactions

Moderate

tafenoquine food

Applies to: tafenoquine

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of tafenoquine. According to the manufacturer, tafenoquine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 31% and 41%, respectively, when administered as an investigational capsule formulation with a high-calorie, high-fat meal (approximately 1000 calories; 15% protein, 25% carbohydrate, 60% fat) relative to the fasted state.

MANAGEMENT: Tafenoquine should be administered with food.

References (1)
  1. (2018) "Product Information. Krintafel (tafenoquine)." GlaxoSmithKline

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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