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Drug Interactions between Clolar and daclatasvir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

clofarabine daclatasvir

Applies to: Clolar (clofarabine) and daclatasvir

MONITOR: Coadministration with daclatasvir may increase the systemic exposure and risk of adverse effects of drugs that are substrates of the hepatic uptake transporter, organic cation transporter 1 (OCT1). The proposed mechanism is decreased clearance due to daclatasvir-mediated inhibition of OCT1. The clinical significance is unknown.

MANAGEMENT: Caution is advised if daclatasvir is used concomitantly with drugs that are substrates of OCT1, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever daclatasvir is added to or withdrawn from therapy with these drugs. Patients should also be monitored for the development of adverse effects.

References (1)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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