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Drug Interactions between clofarabine and Juluca

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

clofarabine rilpivirine

Applies to: clofarabine and Juluca (dolutegravir / rilpivirine)

Clofarabine may cause liver problems, and using it with other medications that can also affect the liver such as rilpivirine may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

clofarabine dolutegravir

Applies to: clofarabine and Juluca (dolutegravir / rilpivirine)

Dolutegravir may increase the blood levels and effects of clofarabine. You may need a dose adjustment if you have been receiving clofarabine and are starting treatment with dolutegravir. Likewise, if you have been receiving both medications, the dose of clofarabine may need to be adjusted if dolutegravir is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

rilpivirine food

Applies to: Juluca (dolutegravir / rilpivirine)

Food significantly increases the absorption of rilpivirine. You should take each dose of rilpivirine with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Grapefruit juice can also increase the absorption of rilpivirine and should preferably be avoided.

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Minor

dolutegravir food

Applies to: Juluca (dolutegravir / rilpivirine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer