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Drug Interactions between choline salicylate / magnesium salicylate and niacin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

choline salicylate magnesium salicylate

Applies to: choline salicylate / magnesium salicylate and choline salicylate / magnesium salicylate

GENERALLY AVOID: Concomitant use of more than one salicylate at a time may increase the potential for gastrointestinal adverse effects (e.g., inflammation, pain, bleeding, ulceration) and bruising or bleeding.

MANAGEMENT: Concomitant use of more than one salicylate at a time should generally be avoided. Patients treated with a salicylate should be advised to take it with food and to immediately report signs and symptoms of GI ulceration and bleeding such as severe abdominal pain, dizziness, lightheadedness, and the appearance of black, tarry stools.

References (2)
  1. (2001) "Product Information. Pepto-Bismol (bismuth subsalicylate)." Procter and Gamble Pharmaceuticals
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
Minor

niacin choline salicylate

Applies to: niacin and choline salicylate / magnesium salicylate

Salicylates may cause an elevation in serum levels of nicotinic acid. The mechanism is not completely understood. However, salicylates also significantly decrease the serum levels of nicotinuric acid--a metabolite--and some experts hypothesize that salicylic acid causes a concentration-dependent decrease in the total clearance of nicotinic acid. Such a decrease would result in the saturation of the nicotinuric acid conjugation pathway. Data are available for aspirin only. No special precautions appear to be necessary.

References (1)
  1. Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ (1989) "Pharmacokinetics of nicotinic acid-salicylic acid interaction." Clin Pharmacol Ther, 46, p. 642-7
Minor

niacin magnesium salicylate

Applies to: niacin and choline salicylate / magnesium salicylate

Salicylates may cause an elevation in serum levels of nicotinic acid. The mechanism is not completely understood. However, salicylates also significantly decrease the serum levels of nicotinuric acid--a metabolite--and some experts hypothesize that salicylic acid causes a concentration-dependent decrease in the total clearance of nicotinic acid. Such a decrease would result in the saturation of the nicotinuric acid conjugation pathway. Data are available for aspirin only. No special precautions appear to be necessary.

References (1)
  1. Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ (1989) "Pharmacokinetics of nicotinic acid-salicylic acid interaction." Clin Pharmacol Ther, 46, p. 642-7

Drug and food interactions

Moderate

niacin food

Applies to: niacin

GENERALLY AVOID: Ethanol can exacerbate the cutaneous flushing that is a common side effect of niacin. At least one case of delirium and lactic acidosis has been reported with coadministration of these drugs, although data are limited.

MANAGEMENT: Coadministration should probably be discouraged, particularly since chronic consumption of large amounts of alcohol is associated with hyperlipidemia.

References (1)
  1. Schwab RA, Bachhuber BH (1991) "Delirium and lactic acidosis caused by ethanol and niacin coingestion." Am J Emerg Med, 9, p. 363-5
Moderate

magnesium salicylate food

Applies to: choline salicylate / magnesium salicylate

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Minor

niacin food

Applies to: niacin

A single case has been reported in which cutaneous flushing and tremors were noted in a woman who was taking niacin while wearing a nicotine patch. The mechanism is suspected to be synergistic cutaneous vasodilatory effects. The clinical significance of this possible interaction is not known.

References (1)
  1. Rockwell KA Jr (1993) "Potential interaction between niacin and transdermal nicotine." Ann Pharmacother, 27, p. 1283-8

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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