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Drug Interactions between cholestyramine and pravastatin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cholestyramine pravastatin

Applies to: cholestyramine and pravastatin

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Bile acid sequestrants such as cholestyramine or colestipol may bind to and decrease the bioavailability of pravastatin. Although the lipid-lowering effects of pravastatin and bile acid sequestrants may be enhanced when combined, concomitant administration has resulted in an approximately 40% to 50% decrease in mean pravastatin exposure (AUC), which may lessen its effectiveness. By contrast, no clinically significant reduction in bioavailability or therapeutic effect was observed when pravastatin was administered 1 hour before or 4 hours after cholestyramine or 1 hour before colestipol and a standard meal.

MANAGEMENT: When prescribed with cholestyramine or colestipol, pravastatin should be administered at least one hour before or four hours after the bile acid sequestrant.

Drug and food interactions

Moderate

pravastatin food

Applies to: pravastatin

Pravastatin may cause liver problems and using it with substantial quantities of ethanol (alcohol) may increase that risk. You should limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cholestyramine food

Applies to: cholestyramine

Using cholestyramine together with multivitamin with minerals may decrease the effects of multivitamin with minerals. Multivitamin with minerals should be administered at least 4 hours before cholestyramine. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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