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Drug Interactions between Choledyl and grepafloxacin

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

oxtriphylline grepafloxacin

Applies to: Choledyl (oxtriphylline) and grepafloxacin

ADJUST DOSE: The coadministration with grepafloxacin may increase the serum concentrations of theophylline. The mechanism is grepafloxacin inhibition of CYP450 1A2, the isoenzyme primarily responsible for the metabolic clearance of theophylline. In 12 healthy volunteers maintained on theophylline to produce a mean serum concentration of 7.5 mg/L, administration of grepafloxacin (600 mg orally once a day for 10 days) increased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC) of theophylline by about 80% and 100%, respectively. Apparent total clearance (Cl/F) was reduced by approximately 50%. Theophylline had no effect on the pharmacokinetics of grepafloxacin.

MANAGEMENT: A 50% reduction in theophylline maintenance dosage is recommended during grepafloxacin treatment, and serum theophylline levels should be monitored to further guide any therapy adjustments. Patients should be advised to notify their physician if they experience possible signs of theophylline toxicity such as nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeats.

References

  1. "Product Information. Raxar (grepafloxacin)." Glaxo Wellcome PROD (2001):
  2. Efthymiopoulos C, Bramer SL, Maroli A, Blum B "Theophylline and warfarin interaction studies with grepafloxacin." Clin Pharmacokinet 33(Suppl 1) (1997): 39-46

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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