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Drug Interactions between Choledyl SA and Cognex

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

oxtriphylline tacrine

Applies to: Choledyl SA (oxtriphylline) and Cognex (tacrine)

ADJUST DOSE: Tacrine may increase plasma theophylline levels twofold and increase the elimination half-life of theophylline. The mechanism is probably related to the fact that both agents are metabolized by CYP450 1A2. Other hepatically metabolized methylxanthines may also be affected.

MANAGEMENT: If tacrine and a theophylline must be used concomitantly, dosage reductions are recommended, as is close observation for evidence of altered clinical and laboratory effects. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.

References

  1. (2001) "Product Information. Cognex (tacrine)." Parke-Davis

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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