Drug Interactions between chlorpheniramine / dihydrocodeine / phenylephrine and st. john's wort

Using chlorpheniramine together with dihydrocodeine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Using chlorpheniramine together with St. John's wort may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

St. John's wort may reduce the blood levels of dihydrocodeine, which may make dihydrocodeine less effective in treating your condition. If you have been receiving treatment with dihydrocodeine, adding St. John's wort may cause you to experience unpleasant withdrawal symptoms such as anxiety, tremor, rapid heartbeat and nausea. On the other hand, if you have been receiving both medications, suddenly discontinuing St. John's wort may increase the blood levels of dihydrocodeine, which could increase or prolong its adverse effects. In addition, using dihydrocodeine together with St. John's wort can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as hallucinations, seizures, increased heart rate, fever, excessive sweating, blurred vision, tremor, nausea, vomiting, and diarrhea. You should contact your doctor immediately if you experience these symptoms during treatment. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.