Can you take Chlorotrianisene with Daridorexant?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- chlorotrianisene
- daridorexant
Drug interactions
Moderate drug interactions
Moderate:
chlorotrianisene daridorexant
Applies to: chlorotrianisene and daridorexant
Daridorexant may increase the blood levels and effects of chlorotrianisene. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
daridorexant Food/Lifestyle
Applies to: daridorexant
Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with daridorexant unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of daridorexant. This may increase the risk of side effects such as somnolence, fatigue, abnormal sleep behaviors, worsening of depression or suicidal thoughts, or headache. You should avoid the use of alcohol while being treated with daridorexant. Alcohol can increase the nervous system side effects of daridorexant such as dizziness, drowsiness, and reduced coordination. Some people may also experience complex sleep behaviors such as sleepwalking, sleep driving, preparing and eating food or doing other activities while not fully awake that you may not remember the next morning. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Minor food/lifestyle interactions
Minor:
chlorotrianisene Food/Lifestyle
Applies to: chlorotrianisene
Information for this minor interaction is available on the professional version.
Disease interactions
6 potential interactions Applies to: 6 conditions, including Depression, Narcolepsy, Liver Disease, Drug Dependence, and Alcoholism.
Alcoholism
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Alcoholism.
Patients with a history of abuse or addiction to alcohol or other substances may be at increased risk for abuse of or addiction to daridorexant and should be monitored closely.
Depression
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Depression.
Daridorexant can worsen depression and suicidal thoughts and actions and should be used with caution in patients with depression. These patients should be monitored closely and any preventive measures should be taken.
Drug Dependence
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Drug Dependence.
Patients with a history of abuse or addiction to alcohol or other substances may be at increased risk for abuse of or addiction to daridorexant and should be monitored closely.
Liver Disease
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Liver Disease.
Daridorexant is not recommended in patients with severe hepatic dysfunction. The maximum recommended dosage in patients with moderate hepatic dysfunction is 25 mg once per night.
Narcolepsy
Major:
daridorexant
Daridorexant has a major potential interaction with Narcolepsy.
Daridorexant is contraindicated in patients with narcolepsy.
Pulmonary Impairment
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Pulmonary Impairment.
Daridorexant is a respiratory depressant and should be used with caution if prescribed to patients with impaired respiratory function. This drug has not been studied in patients with moderate to severe sleep apnea requiring CPAP or in patients with severe chronic obstructive pulmonary disease (COPD).
Report options
More resources
chlorotrianisene
A total of 260 drugs are known to interact with chlorotrianisene.
- Chlorotrianisene is in the drug class estrogens.
- Chlorotrianisene is used to treat Postmenopausal Symptoms.
daridorexant
A total of 778 drugs are known to interact with daridorexant.
- Daridorexant is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Daridorexant is used to treat Insomnia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.