Drug Interactions between chloramphenicol and Prograf
This report displays the potential drug interactions for the following 2 drugs:
- chloramphenicol
- Prograf (tacrolimus)
Interactions between your drugs
chloramphenicol tacrolimus
Applies to: chloramphenicol and Prograf (tacrolimus)
MONITOR: Limited clinical data suggest that chloramphenicol may significantly increase tacrolimus blood concentrations. Inhibition of tacrolimus metabolism by chloramphenicol may be the mechanism of this interaction.
MANAGEMENT: Patients should be monitored for clinical and laboratory evidence of tacrolimus toxicity (nephrotoxicity and neurotoxicity) if chloramphenicol is to be added to or removed from the drug regimen. Patients should be advised to report symptoms such as tremors, headache, fatigue, or lethargy.
References
- Schulman SL, Shaw LM, Jabs K, Leonard MB, Brayman KL (1998) "Interaction between tacrolimus and chloramphenicol in a renal transplant recipient." Transplantation, 65, p. 1397-8
- Taber DJ, Dupuis RE, Hollar KD, Strzalka AL, Johnson MW (2000) "Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient." Transplant Proc, 32, p. 660-2
Drug and food interactions
tacrolimus food
Applies to: Prograf (tacrolimus)
ADJUST DOSING INTERVAL: Consumption of food has led to a 27% decrease in the bioavailability of orally administered tacrolimus.
MANAGEMENT: Tacrolimus should be administered at least one hour before or two hours after meals.
GENERALLY AVOID: Grapefruit juice has been reported to increase tacrolimus trough concentrations. Data are limited, but inhibition of the CYP450 enzyme system appears to be involved.
MANAGEMENT: The clinician may want to recommend that the patient avoid ingesting large amounts of grapefruit juice while taking tacrolimus.
References
- (2001) "Product Information. Prograf (tacrolimus)." Fujisawa
- Hooks MA (1994) "Tacrolimus, a new immunosuppressant--a review of the literature." Ann Pharmacother, 28, p. 501-11
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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