Drug interactions between chlorambucil and Taxotere
Interactions between your drugs
Applies to: chlorambucil and Taxotere (docetaxel)
Consumer information for this interaction is not currently available.
MONITOR: The concomitant or sequential administration of multiple antineoplastic agents may result in additive toxicities, particularly in the bone marrow and gastrointestinal tract.
MANAGEMENT: Close clinical and laboratory monitoring for hematologic and nonhematologic toxicities are recommended when antineoplastic agents are administered concurrently or during close intervals. Dosing adjustments may be necessary. The manufacturers' recommendations and institutional protocols for dosage, treatment regimens, monitoring, and management of toxicities should be consulted.
- "Product Information. Ellence (epirubicin)" Pharmacia and Upjohn, Kalamazoo, MI.
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ():
- "Product Information. Fluorouracil injection (fluorouracil)." Roche Laboratories, Nutley, NJ.
- "Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb, Princeton, NJ.
- "Product Information. Paraplatin (carboplatin)." Bristol-Myers Squibb, Princeton, NJ.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn, Kalamazoo, MI.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Drug and food interactions
Applies to: Taxotere (docetaxel)
You should preferably avoid the regular consumption of grapefruits and grapefruit juice while taking DOCEtaxel. Grapefruit and grapefruit juice can significantly increase the blood levels of DOCEtaxel. This may increase the risk of side effects such as nausea, vomiting, diarrhea, mouth sores, fluid retention, nerve pain, numbness, tingling, muscle pain or weakness, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|