Skip to main content

Drug Interactions between Cytoxan and Chloracol

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Minor

chloramphenicol cycloPHOSphamide

Applies to: Chloracol (chloramphenicol) and Cytoxan (cyclophosphamide)

Chloramphenicol may inhibit the hepatic metabolism of cyclophosphamide. Since cyclophosphamide requires hepatic metabolism to be active (it is a prodrug with active metabolites), activation may be delayed or decreased and half-life may be increased. The effectiveness of cyclophosphamide could be decreased, although the clinical significance of the interaction is unclear. Monitoring of cyclophosphamide effectiveness during coadministration is recommended.

References

  1. Ambrose PJ (1984) "Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate." Clin Pharmacokinet, 9, p. 222-38
  2. Mouridsen HT, Witten J, Frederiksen PL, Hulsbaek I (1978) "Studies on the correlation between rate of biotransformation and haematological toxicity of cyclophosphamide ." Acta Pharmacol Toxicol (Copenh), 43, p. 328-30
  3. Faber OK, Mouridsen HT, Skovsted L (1975) "The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man." Br J Clin Pharmacol, 2, p. 281-5

Switch to consumer interaction data

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer