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Can you take Chikungunya vaccine, live (cvx 317) with Muromonab-cd3?

1 drug interaction and 9 additional warnings found for the following 2 drugs:

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Drug interactions

Major drug interactions

Major:

muromonab-CD3 chikungunya vaccine, live (cvx 317)

Applies to: muromonab-cd3 and chikungunya vaccine, live (cvx 317)

If you are currently being treated or have recently been treated with muromonab-CD3, you should let your doctor know before receiving chikungunya vaccine, live (cvx 317). Depending on the dose and length of time you have been on muromonab-CD3, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of muromonab-CD3 therapy. Conversely, if you have recently been vaccinated with chikungunya vaccine, live (cvx 317), your doctor may choose to postpone treatment with muromonab-CD3 for a few weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

9 potential interactions Applies to: 9 conditions, including Heart Failure, Seizures, Arrhythmia, Fever, and Head Injury.

Arrhythmia

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Arrhythmia.

The use of muromonab-CD3 is contraindicated in patients with uncompensated heart failure. Cardiovascular collapse, cardiac arrest, severe hypotension, shock, left ventricular dysfunction, and arrhythmias have occurred in patients administered muromonab-CD3. Patients with cardiovascular impairments are at increased risk for more serious cardiorespiratory complications (respiratory arrest, failure, distress, and/or cardiovascular collapse, cardiac arrest, angina, or myocardial infarction) from muromonab-CD3-associated Cytokine Release Syndrome.

Cerebral Vascular Disorder

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Cerebral Vascular Disorder.

The use of muromonab-CD3 is contraindicated in patients with or predisposed to seizures. Seizures, cerebral edema, confusion, auditory/visual hallucinations, mental status changes, psychosis, mania, lethargy, stupor, or coma have occurred in patients administered muromonab-CD3. Patient with CNS disorders, cerebrovascular disease, neurological disturbances are at increased risk for neuro/psychiatric events.

Fever

Moderate:

muromonab-cd3

muromonab-CD3 has a moderate potential interaction with Fever.

Muromonab-CD3 should not be administered in the presence of a body temperature of 100 degrees F (38.7 degrees C) or greater. Spiking fever (to 107 degrees F) associated with the Cytokine Release Syndrome have occurred. Antipyretics may be administered to reduce body temperature in this setting.

Fluid Retention

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Fluid Retention.

The use of muromonab-CD3 is contraindicated in patients with fluid overload as evidences by chest X-ray or a 3% or more weight gain in the week prior to muromonab-CD3 therapy. Patients with fluid overload are at increased risk for more serious cardiopulmonary complications (respiratory arrest, failure, distress, and/or cardiovascular collapse, cardiac arrest, angina, or myocardial infarction) from muromonab-CD3-associated Cytokine Release Syndrome.

Head Injury

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Head Injury.

The use of muromonab-CD3 is contraindicated in patients with or predisposed to seizures. Seizures, cerebral edema, confusion, auditory/visual hallucinations, mental status changes, psychosis, mania, lethargy, stupor, or coma have occurred in patients administered muromonab-CD3. Patient with CNS disorders, cerebrovascular disease, neurological disturbances are at increased risk for neuro/psychiatric events.

Heart Failure

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Heart Failure.

The use of muromonab-CD3 is contraindicated in patients with uncompensated heart failure. Cardiovascular collapse, cardiac arrest, severe hypotension, shock, left ventricular dysfunction, and arrhythmias have occurred in patients administered muromonab-CD3. Patients with cardiovascular impairments are at increased risk for more serious cardiorespiratory complications (respiratory arrest, failure, distress, and/or cardiovascular collapse, cardiac arrest, angina, or myocardial infarction) from muromonab-CD3-associated Cytokine Release Syndrome.

Immunodeficiency

Moderate:

chikungunya vaccine, live (cvx 317)

Chikungunya vaccine, live (cvx 317) has a moderate potential interaction with Immunodeficiency.

The expected antibody responses may not be obtained when live attenuated vaccines and/or toxoids are administered to immunosuppressed persons, including those receiving immunosuppressive therapy. Caution and close monitoring is advised.

Ischemic Heart Disease

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Ischemic Heart Disease.

The use of muromonab-CD3 is contraindicated in patients with uncompensated heart failure. Cardiovascular collapse, cardiac arrest, severe hypotension, shock, left ventricular dysfunction, and arrhythmias have occurred in patients administered muromonab-CD3. Patients with cardiovascular impairments are at increased risk for more serious cardiorespiratory complications (respiratory arrest, failure, distress, and/or cardiovascular collapse, cardiac arrest, angina, or myocardial infarction) from muromonab-CD3-associated Cytokine Release Syndrome.

Seizures

Major:

muromonab-cd3

muromonab-CD3 has a major potential interaction with Seizures.

The use of muromonab-CD3 is contraindicated in patients with or predisposed to seizures. Seizures, cerebral edema, confusion, auditory/visual hallucinations, mental status changes, psychosis, mania, lethargy, stupor, or coma have occurred in patients administered muromonab-CD3. Patient with CNS disorders, cerebrovascular disease, neurological disturbances are at increased risk for neuro/psychiatric events.

More resources

chikungunya vaccine, live (cvx 317)

A total of 379 drugs are known to interact with chikungunya vaccine, live (cvx 317).

muromonab-cd3

A total of 185 drugs are known to interact with muromonab-cd3.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.