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Drug Interactions between charcoal / sorbitol and ipecac

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

charcoal ipecac

Applies to: charcoal / sorbitol and ipecac

GENERALLY AVOID: Administration of activated charcoal with ipecac may decrease the effectiveness of the ipecac. The alkaloids of ipecac may be adsorbed onto the charcoal. The concomitant use of ipecac and charcoal does not appear to improve patient outcome over charcoal alone.

MANAGEMENT: Ipecac and activated charcoal are generally not administered together routinely; although the prior administration of one agent should not be considered a contraindication to the administration of the other agent if it is deemed necessary by the attending physician. If both agents are used to treat a patient, the ipecac is generally given first and the charcoal is given after vomiting has stopped.

References

  1. Covington TR, eds., Lawson LC, Young LL "Handbook of Nonprescription Drugs." Washington, DC: American Pharmaceutical Association (1993):
  2. Chyka PA, Seger D "Position statement: single-dose activated charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres an Clinical Toxicologists." J Toxicol Clin Toxicol 35 (1997): 721-41
  3. Krenzelok EP, McGuigan M, Lheur P "Position statement: ipecac syrup. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinica Toxicologists." J Toxicol Clin Toxicol 35 (1997): 699-709
  4. Bond GR "The role of activated charcoal and gastric emptying in gastrointestinal decontamination: A state-of-the-art review." Ann Emerg Med 39 (2002): 273-86
View all 4 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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