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Drug Interactions between Centrum Jr with Extra Calcium and maralixibat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

multivitamin with minerals maralixibat

Applies to: Centrum Jr with Extra Calcium (multivitamin with minerals) and maralixibat

MONITOR: Maralixibat may affect the absorption of fat-soluble vitamins (FSV) including A, D, E, and K. In a clinical study, emergent FSV deficiency was reported in 10% of patients during 48 weeks of treatment. In addition, it should be noted that patients with Alagille syndrome (ALGS) can have FSV deficiency at baseline.

MANAGEMENT: Clinical and laboratory monitoring of serum FSV levels is recommended at baseline and during treatment with maralixibat. If FSV deficiency is diagnosed, supplementation with FSV should be initiated. If FSV deficiency persists or worsens despite adequate FSV supplementation, discontinuation of maralixibat should be considered.

References (1)
  1. (2021) "Product Information. Livmarli (maralixibat)." Mirum Pharmaceuticals, Inc.

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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