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Drug Interactions between cenobamate and Mebaral

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mephobarbital cenobamate

Applies to: Mebaral (mephobarbital) and cenobamate

MONITOR: Coadministration with cenobamate may increase the plasma concentrations and pharmacologic effects of phenobarbital. The proposed mechanism is cenobamate-mediated inhibition of CYP450 2C19, an isoenzyme involved in the hepatic metabolism of phenobarbital. According to the manufacturer, multiple doses of cenobamate (200 mg once daily) increased the mean Cmax and AUC of phenobarbital by 34% and 37%, respectively. Repeated dosing of phenobarbital did not have any significant impact on plasma cenobamate multiple-dose exposure.

MANAGEMENT: Caution is recommended during concomitant use of cenobamate and phenobarbital. Clinical and/or laboratory monitoring are advisable whenever cenobamate is added to or withdrawn from therapy, and the phenobarbital dosage adjusted as necessary.

References

  1. (2020) "Product Information. Xcopri (cenobamate)." SK Life Science, Inc.

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Drug and food interactions

Major

mephobarbital food

Applies to: Mebaral (mephobarbital)

GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.

MANAGEMENT: The combination of ethanol and barbiturates should be avoided.

References

  1. Gupta RC, Kofoed J (1966) "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J, 94, p. 863-5
  2. Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS (1971) "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med, 51, p. 346-51
  3. Saario I, Linnoila M (1976) "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh), 38, p. 382-92
  4. Stead AH, Moffat AC (1983) "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol, 2, p. 5-14
  5. Seixas FA (1979) "Drug/alcohol interactions: avert potential dangers." Geriatrics, 34, p. 89-102
View all 5 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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