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Drug Interactions between cenobamate and Commit

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

nicotine cenobamate

Applies to: Commit (nicotine) and cenobamate

MONITOR: Coadministration with cenobamate may decrease the plasma concentrations and pharmacologic effects of CYP450 2B6 substrates. The proposed mechanism is cenobamate-mediated induction of the CYP450 2B6 isoenzyme. According to the manufacturer, multiple doses of cenobamate (200 mg once daily) reduced the mean Cmax and AUC of bupropion, a CYP450 2B6 substrate, by 23% and 39%, respectively.

MANAGEMENT: Caution is advised if cenobamate is used concomitantly with drugs that are substrates of CYP450 2B6, particularly those with a narrow therapeutic index. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever cenobamate is added to or withdrawn from therapy.

References

  1. (2020) "Product Information. Xcopri (cenobamate)." SK Life Science, Inc.

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Drug and food interactions

Minor

nicotine food

Applies to: Commit (nicotine)

One study (n=12) has reported that there was a significant interactive effect of caffeine and nicotine on subjective arousal such that nicotine decreased arousal only in the presence of caffeine. The exact mechanism of this interaction has not been specified. Further research is needed to examine the subjective and physiological interactions between caffeine and nicotine.

References

  1. Rose JE, Behm FM (1991) "Psychophysiological interactions between caffeine and nicotine." Pharmacol Biochem Behav, 38, p. 333-7

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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