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Drug Interactions between CellCept and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

probenecid mycophenolate mofetil

Applies to: probenecid and CellCept (mycophenolate mofetil)

MONITOR: Animal studies have shown that coadministration with probenecid results in a 2-fold increase in the systemic exposure (AUC) of mycophenolic acid and a 3-fold increase in the AUC of mycophenolic acid glucuronide, an inactive metabolite. The proposed mechanism is competition of these agents for renal tubular secretion.

MANAGEMENT: Caution is advised if mycophenolic acid products must be used concomitantly with probenecid. The dosage of one or both drugs may require adjustments.

References (1)
  1. (2001) "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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