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Drug Interactions between CellCept and isavuconazonium

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mycophenolate mofetil isavuconazonium

Applies to: CellCept (mycophenolate mofetil) and isavuconazonium

MONITOR: Coadministration with isavuconazonium sulfate (prodrug of isavuconazole) may increase the bioavailability of mycophenolic acid. The proposed mechanism is isavuconazole inhibition of the UGT-mediated metabolism of mycophenolic acid. When a single 1 gram dose of mycophenolate mofetil was administered to healthy volunteers following multiple dosing of isavuconazonium sulfate, mycophenolic acid systemic exposure (AUC) increased by nearly 40%.

MANAGEMENT: Caution is advised when mycophenolic acid is prescribed with isavuconazonium sulfate. Clinical and laboratory monitoring are recommended following the addition or withdrawal of isavuconazonium sulfate, and the mycophenolic acid dosage adjusted as necessary.

References (1)
  1. (2015) "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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