Drug Interactions between celecoxib / tramadol and lithium

TraMADol may rarely cause seizures, and combining it with other medications that can also cause seizures such as lithium may increase that risk. You may be more susceptible if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Nonsteroidal anti-inflammatory drugs such as celecoxib may significantly increase the blood levels of lithium in some patients and cause lithium intoxication, which is potentially life-threatening and may require hospitalization. You may be particularly susceptible if you are elderly or have other risk factors such as kidney impairment, congestive heart failure, sodium restriction, and dehydration. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience drowsiness, dizziness, confusion, diarrhea, vomiting, muscle weakness, muscle incoordination, tremor, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, as these may be signs and symptoms of lithium intoxication. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Celecoxib may increase the blood levels and effects of traMADol. If your doctor does prescribe these medications together, you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects or if your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.