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Drug Interactions between cefditoren and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

probenecid cefditoren

Applies to: probenecid and cefditoren

Like other beta-lactam antibiotics, the coadministration with probenecid may increase the plasma concentrations of cefditoren pivoxil. The mechanism is competitive inhibition by probenecid of the renal tubular secretion of these antibiotics. According to the manufacturer, a single dose of probenecid increased the mean peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and half-life of a single dose of cefditoren pivoxil by 49%, 122% and 53%, respectively. While this interaction may be exploited to enhance the antibacterial effect of cefditoren pivoxil, the potential for toxicity should be considered if the normal dosage of cefditoren pivoxil is administered with probenecid. A reduced dosage of cefditoren pivoxil may be required.

References (1)
  1. (2001) "Product Information. Spectracef (cefditoren)." TAP Pharmaceuticals Inc

Drug and food interactions

Moderate

cefditoren food

Applies to: cefditoren

ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of cefditoren pivoxil. According to the manufacturer, administration of cefditoren pivoxil following a high-fat meal increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 50% and 70%, respectively, compared to administration in the fasting state. The absolute bioavailability of cefditoren pivoxil is approximately 14% under fasting conditions and 16% when given with a low-fat meal.

MANAGEMENT: To ensure maximal oral absorption, cefditoren pivoxil should be administered with or immediately after a meal.

References (1)
  1. (2001) "Product Information. Spectracef (cefditoren)." TAP Pharmaceuticals Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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