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Drug Interactions between CeeNU and Vincasar PFS

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

vinCRIStine lomustine

Applies to: Vincasar PFS (vincristine) and CeeNU (lomustine)

Concurrent administration of vincristine and lomustine may lead to an earlier onset and/or increased severity of side effects. The mechanism is the inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and lomustine are used concomitantly, caution and close observation are advised.

References

  1. Zhou-Pan XR, Seree E, Zhou XJ, et al. (1993) "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res, 53, p. 5121-6
  2. (2001) "Product Information. Oncovin (vincristine)." Lilly, Eli and Company

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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