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Drug Interactions between carvedilol and propylthiouracil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

propylthiouracil carvedilol

Applies to: propylthiouracil and carvedilol

MONITOR: The clearance of some beta-blockers with high extraction ratios may be reduced when a euthyroid state is achieved after the addition of antithyroid agents. Sotalol, nadolol, carteolol, and atenolol, which are primarily eliminated by the kidney, do not appear to be affected by changes in thyroid function.

MANAGEMENT: The patient should be closely monitored for altered efficacy and safety while achieving a euthyroid state or when the antithyroid agent dosage is added, discontinued, or changed. Beta blocker dose reductions may be required.

References (5)
  1. Hallengren B, Nilsson OR, Karlberg BE, Melander A, Tegler L, Wahlin-Boll E (1982) "Influence of hyperthyroidism on the kinetics of methimazole, propranolol, metoprolol and atenolol." Eur J Clin Pharmacol, 21, p. 379-84
  2. Feely J, Crooks J, Stevenson IH (1981) "Plasma propranolol steady state concentrations in thyroid disorders." Eur J Clin Pharmacol, 19, p. 329-33
  3. Feely J, Stevenson IH, Crooks J (1981) "Increased clearance of propranolol in thyrotoxicosis." Ann Intern Med, 94, p. 472-4
  4. Aro A, Anttila M, Korhonen T, Sundquist H (1982) "Pharmacokinetics of propranolol and sotalol in hyperthyroidism." Eur J Clin Pharmacol, 21, p. 373-7
  5. Feely J, Crooks J, Stevenson IH (1981) "The influence of age, smoking and hyperthyroidism on plasma propranolol steady state concentration." Br J Clin Pharmacol, 12, p. 73-8

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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