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Drug Interactions between carboplatin and fosphenytoin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

CARBOplatin fosphenytoin

Applies to: carboplatin and fosphenytoin

MONITOR: Carboplatin may decrease serum phenytoin levels. Loss of seizure control may result. The mechanism of this interaction is unknown. It is not know if carboplatin will interact in a similar manner with other hydantoins.

MANAGEMENT: If carboplatin and phenytoin must be used together, close clinical and laboratory observation for evidence of altered phenytoin effect is recommended. Patients should be advised to notify their caregiver if they experience loss of seizure control.

References (1)
  1. Dofferhoff AS, Berendsen HH, Naalt J, et al. (1990) "Decreased phenytoin level after carboplatin treatment." Am J Med, 89, p. 247-8

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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